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Gavril W Pasternak Selected Research

iodobenzoylnaltrexamide

7/2021Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain.
1/2018Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia.
7/2015Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
10/2014Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene.
9/2014Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.

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Gavril W Pasternak Research Topics

Disease

21Pain (Aches)
11/2021 - 01/2002
13Respiratory Insufficiency (Respiratory Failure)
01/2021 - 12/2011
4Opioid-Related Disorders (Opiate Addiction)
01/2020 - 02/2009
4Neoplasms (Cancer)
06/2014 - 07/2005
3Chronic Pain
01/2020 - 12/2003
2Alcoholism (Alcohol Abuse)
01/2021 - 01/2020
2Neuroblastoma
01/2019 - 04/2010
2Neuralgia (Stump Neuralgia)
01/2018 - 07/2015
2Hyperalgesia
06/2017 - 09/2009
2Cancer Pain
01/2017 - 01/2015
2Constipation
01/2016 - 12/2011
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
11/2021
1Morphine Dependence
04/2017
1Mental Disorders (Mental Disorder)
01/2017
1Cocaine-Related Disorders (Cocaine Addiction)
11/2015
1Hypersensitivity (Allergy)
10/2014
1Heroin Dependence (Heroin Abuse)
08/2014
1Adenocarcinoma
11/2013
1Hypoglycemia (Reactive Hypoglycemia)
05/2013
1Breakthrough Pain
02/2009
1Glioma (Gliomas)
07/2005
1Weight Loss (Weight Reduction)
11/2002

Drug/Important Bio-Agent (IBA)

20Opioid Analgesics (Opioids)IBA
11/2021 - 12/2003
14Morphine (MS Contin)FDA LinkGeneric
01/2021 - 11/2007
13Analgesics (Analgesic Drugs)IBA
07/2021 - 12/2003
7mu Opioid Receptors (mu Opioid Receptor)IBA
01/2020 - 01/2010
6Opioid Receptors (Opioid Receptor)IBA
07/2015 - 04/2010
5iodobenzoylnaltrexamideIBA
07/2021 - 09/2014
4Opiate AlkaloidsIBA
07/2021 - 11/2007
3Pharmaceutical PreparationsIBA
01/2020 - 12/2003
3LigandsIBA
11/2013 - 07/2005
2GTP-Binding Proteins (G-Protein)IBA
01/2020 - 01/2019
2Heroin (Diamorphine)IBA
01/2018 - 08/2014
2Proteins (Proteins, Gene)FDA Link
01/2017 - 09/2012
2Methadone (Dolophine)FDA LinkGeneric
05/2013 - 02/2009
1hirsutineIBA
01/2021
1corynoxineIBA
01/2021
1ArrestinIBA
01/2021
1carfentanil (carfentanyl)IBA
01/2020
1mitragynineIBA
01/2020
1AmidesIBA
01/2020
1Levorphanol (Levo-Dromoran)FDA LinkGeneric
01/2019
1Biological ProductsIBA
01/2019
1Circular RNAIBA
01/2019
16-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA
01/2016
1delta Opioid Receptors (delta Opioid Receptor)IBA
11/2015
1Freund's AdjuvantIBA
10/2014
1RNA Precursors (Precursor, mRNA)IBA
08/2014
1Membrane Proteins (Integral Membrane Proteins)IBA
11/2013
1Blood Glucose (Blood Sugar)IBA
05/2013
1GuanosineIBA
04/2010
1Guanosine 5'-O-(3-Thiotriphosphate)IBA
04/2010
1triphosphoric acid (triphosphate)IBA
04/2010
1Formaldehyde (Formol)FDA Link
09/2009
1Protein Isoforms (Isoforms)IBA
09/2009
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
09/2009
1O,O-diisopropyl-S-benzylthiophosphate (IBP)IBA
07/2005
1GABA-A Receptors (GABA(A) Receptor)IBA
07/2005
1isoquinolineIBA
07/2005
1Carrier Proteins (Binding Protein)IBA
07/2005
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
04/2005
1Ibuprofen (Motrin)FDA LinkGeneric
12/2003
1Hydrocodone (Dihydrocodeinone)FDA LinkGeneric
12/2003
1Gs GTP-Binding Protein alpha Subunits (G(s)alpha)IBA
11/2002
1Antisense Elements (Genetics)IBA
11/2002
1Peptides (Polypeptides)IBA
01/2002

Therapy/Procedure

4Analgesia
01/2021 - 12/2011
4Therapeutics
11/2013 - 02/2009
2Pain Management
06/2014 - 03/2012
1Self Medication
01/2020